mRNA VACCINES AGAINST SARS-COV-2: A MILESTONE IN THE HISTORY OF SCIENCE

Abstract

There is no doubt that vaccines have been the main tool that medicine has used to fight many infectious diseases from the time of Luis Pasteur with the development of his vaccine against the rabies virus until the eradication of smallpox from the earth.

Five vaccine platforms have been developed from the classical to the most modern: live attenuated, killed, recombinant, recombinant viral and nucleic acids. The fact that there is no ideal vaccine because of all of them presents advantages and disadvantages has led modern science to develop new strategies every day to awaken both a humoral and cellular immune response, which are safe, low-cost and accessible by any health system of the planet.

In the following review, the status of the different platforms against the fight of the SARS-Cov2 pandemic is observed, emphasizing those of messenger RNA that for the first time in the history of humanity have been approved as emergency use against covid 19.